Syngeneic mouse models are preclinical in vivo models used to evaluate therapeutic candidates in mice with intact immune system. Humanized mouse models support the engraftment of many functional components of the human immune system. This Quick Guide gives a comparison of the two models and weighs the advantages and challenges of these models for oncology research.
Syngeneic and humanized mouse models have helped advance immune-oncology preclinical research and accelerated the screening and evaluation of novel therapeutics. In our blog, we highlight the features of each model and highlight their relevancy in different phases of preclinical IO research.
