Publications

Peer Reviewed Publications

September 2017
Current Protocols in Pharmacology: Development and applications of patient-derived xenograft models in humanized mice for oncology and immune-oncology drug discovery
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October 2017
Annals of Oncology: Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors
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White Paper

Champions Oncology Acute Myeloid Leukemia Models for Ex Vivo and In Vivo Study
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Case Study

Champions TumorGrafts Guide the Development of a Novel, Selective Dual BRAF/EGFR Inhibitor, CEP-32496Case StudyIdentifying and developing targeted oncology compounds is often an arduous, costly and time-consuming process.

As the demand for effective personalized oncology therapies grow, so does the need for a more predictive model solution.

Champions Oncology’s predictive patient-derived xenograft (PDX) models, Champions TumorGrafts, helps bridge the translational gap in oncology drug development by providing a highly-focused and accelerated simulated clinical trial.

The value of Champions TumorGrafts are demonstrated in our latest case study, which shows how the utilization of our PDX models in a screening and efficacy evaluation impacted the development of a novel compound, the dual BRAF-EGR inhibitor, CEP-32496.

Click here to download a pdf file of the case study:
Download the Case Study

Media Coverage

December 15, 2014
Associated Press: Cancer Patients Testing Drugs on Mouse ‘Avatars’
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October 1, 2014
MedPage Today: Patient-Derived Xenografts Accurately Capture Clinical Responses to Treatment
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September 22, 2014
CTV News: ‘Precision Medicine’ Offers Hope for Liposarcoma Tumours
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August 11, 2014
MIT Technology Review: A Mouse with the Same Cancer as You
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June 13, 2014
Newsweek: The Perfect Drug
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April 29, 2014
NBC News: Mouse Avatars Allow Cancer Patients to Test Cures
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February 21, 2014
The Strait Times: Cancer Procedure Tested in Singapore May Lead to More Precise Treatments
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February 13, 2014
Bloomberg BusinessWeek: Mouse Avatars for Testing Chemotherapy Drugs
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April 18, 2013
National Post: Experimental Cancer Test Grafts Tumours into Mice to Create Customized Treatment
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April 18, 2013
NBC New York: NJ Boy Battling Cancer May Have Found Breakthrough Treatment
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September 25, 2012
New York Times: Seeking Cures, Patients Enlist Mice Stand-Ins
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