EORTC 2018 – Patient-derived xenograft (PDX) models from metastatic castration-resistant prostate cancer (mCRPC) patients reflect clinical disease and therapeutic outcomes

Title

Patient-derived xenograft (PDX) models from metastatic castration-resistant prostate cancer (mCRPC) patients reflect clinical disease and therapeutic outcomes

Authors

Daniel Ciznadija1, Peter Kipp1, Manish Kohli2, Swetha Tati1, Maria Mancini1, and Angela Davies1,*
1 Champions Oncology, USA. 2 Mayo Clinic, USA. * Current affiliation: Celgene, USA

Abstract

Prostate cancer (PC) is a leading cause of cancer-related mortality in men and prognosis for mCRPC remains poor despite the availability of novel therapies including androgen receptor (AR) pathway inhibitors. Integration of drug screening and sequencing in PDX models may allow for precision medicine in mCRPC by advancing our understanding of resistance mechanisms (de novo and acquired) and identification of clinical response biomarkers. Here we highlight a cohort of PDX models developed from the bone metastases of mCRPC patients and demonstrate alignment of genomic features with clinical genetics as well as recapitulation of parent tumor histology and patient responses to therapy.