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 Hematological VitroScreen

The leading Ex vivo screening platform for blood cancer therapeutics, showcasing the most extensive collection of rare, clinically significant blood cancer models, including AML, ALL, CLL, MCL, MDS, and MM.

Enrolling only until December 16th, 2024

 

 

Transform Your Blood Cancer Research with Our Extensive Bank

Advance your blood cancer research by leveraging the largest bank of extremely difficult-to-source, never-passaged primary models of hematological malignancies, featuring models of Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Chronic Lymphocytic Leukemia (CLL), Mantle Cell Lymphoma (MCL), Multiple Myeloma (MM), and Myelodysplastic Syndrome (MDS). These clinically relevant models offer heterogeneous responses, mirroring those observed in patients, ensuring dependable outcomes crucial for advancing your drug discovery efforts with confidence.

Clinically Relevant Models

Bank of 81 primary patient blood cancer models that correlate with clinical outcomes

Industry's Largest Bank

Includes models representing major blood cancers including AML, ALL, CLL, MCL, MM, & MDS

Multi-omic Characterization

Clinical annotations coupled with molecular datasets and clinical responses

Features the industry's largest bank of deeply characterized models:

  • 30 primary models of Acute Myeloid Leukemia (AML)
  • 6 primary models of T-cell Acute Lymphoblastic Leukemia (T-ALL)
  • 8 primary models of B-cell Acute Lymphoblastic Leukemia (B-ALL) 
  • 10 primary models of Chronic Lymphocytic Leukemia (CLL)
  • 8 primary models of Mantle Cell Lymphoma (MCL)
  • 5 primary models of Multiple Myeloma (MM)
  • 6 primary models of Myelodysplastic Syndrome (MDS)

 

An ideal platform for ex vivo drug screening:
  • Model Characterization analysis is available with clinical metadata, NGS, Flow Cytometry, and Proteomics.
  • Carefully curated models with ex vivo and in vivo engraftment capabilities.
  • Co-culture modeling using AML Models with Autologous T Cells for Immuno-oncology therapeutic testing.
  • Multiple endpoint data options available, including Western blot, flow cytometry, and 4D proteomics.
  • 50% off on a Standard of Care agent arm (selected by Champions).
Copy of Heme VitroScreen Workflow + MDS & CMML

Figure 1: The Hematological VitroScreen Workflow

Endpoint options Hematologic screen May 2024

Figure 2: The range of assay endpoints available to customize your VitroScreen results

 

Examplary Responses to Standard of Care (SoC)
Acute Myeloid Leukemia CTG-3950 - Standard of Care
Acute Lymphoblastic Leukemia CTG-2406 - Standard of Care
Chronic Lymphocytic Leukemia CTG-3945 - Standard of Care
Mantle Cell Leukemia CTG-4085 - Standard of Care
Chronic Myelomonocytic Leukemia CTG-4200 - Standard of Care

Comet Assay

Comet Assay_April 2023 For Landing page

Figure 3: CTG-3950 shows extensive DNA damage after treatment with Cisplatin.

Colony Forming Unit Assay (CFU)

AML model CTG-2456 Colony forming assay

 


Figure 4
: Cytarabine inhibits cellular differentiation or proliferation in AML Model CTG-2456.