Clinically Relevant Models
Living & diverse bank of clinically relevant models that correlate with clinical outcomes
Pretreated PDX Models
Established from tumor biopsies from patients pretreated with latest generation therapies
Multi-omic Characterization
Clinical annotations coupled with molecular datasets and in vivo responses
Advance your Biliary Tract Cancer Therapies
Biliary tract cancers (BTCs) pose considerable therapeutic challenges due to their aggressive progression and limited treatment options. To advance research and drug development, Champions has established a distinctive cohort of 20* patient-derived xenograft (PDX) models, representing gallbladder cancer and cholangiocarcinoma. These clinically relevant models are derived from patients with advanced, metastatic BTCs who have undergone multiple lines of treatment, including chemotherapy, targeted therapy, and immunotherapy, while preserving key molecular characteristics and driver mutations. (*Model numbers fluctuate as our dataset continuously evolves.)
Champions' premier biliary tract models cohort showcases low-passage models, each reflecting key clinical characteristics, mutations, and pretreatment history.
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Access to a robust bank of biliary tract cancer PDX models with clinically relevant molecular
and pathological characteristics. -
Access to highly characterized PDX models with High Complexity Flow Cytometry, WES, RNAseq, Proteomics, and Phosphoproteomics.
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Includes models pretreated with advanced therapies like Cisplatin, Epirubicin, Capecitabine, and more.