Champions' PDX Models for Evaluating Novel Therapeutics Targeting the DNA Damage Response Mechanism

Cells have evolved numerous redundant mechanisms to repair damage to genomic DNA resulting from intracellular processes including replication stress, inappropriate nuclease activity, metabolic generation of reactive oxygen species, and exogenous insults from exposure to genotoxic agents such as ultraviolet light and DNA-damaging chemicals. These can all lead to senescence, mitotic catastrophe, and eventually apoptosis.

In this case study, you can learn more about how AstraZeneca selected Champions' PDX models that reflect various DNA repair-deficient backgrounds in order to continue developing their DNA-PKc inhibitor.