Why choose the Champions 10 model SynScreen?
10 Syngeneic Models
Screen including syngeneic models with a fully functioning, intact murine immune system
Significant Cost-Saving
Cost-effective and large-scale syngeneic studies compared to the standalone studies
Multiple Endpoint Analyses
Flow cytometry, IHC, Luminex/ELISA and more options to quantify efficacy & mechanism
Champions' premier 10 Model SynScreen is an optimal platform for preclinical testing of Immuno-Oncology therapeutics. It is an advanced syngeneic screen to evaluate efficacy and study the mechanisms of novel immunotherapies in an intact murine immune system.
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Cost-effective, large-scale syngeneic studies across 10 lines can be conducted simultaneously, with 2-3 models starting every two weeks.
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Available models include MC38, CT26, LLC, 4T1, EMT6, B16F10, RENCA, A20, KLN205, and MyC-CaP.
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Multiple endpoint analyses options including options as Flow Cytometry, Luminex/ELISA, IHC and more.
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Each model offers 20 arms, with 10 animals per arm.
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A free PBS control arm is provided (n=10 per model).
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Enjoy 50% off a checkpoint inhibitor arm (PD1, CTLA4, or OX40).
Syngeneic Models - Treated & Untreated Tumor Growth Curves
CT26 responds to both anti-mCTLA4 and anti-mPD1 in vivo, while MC38 responds to anti-mPD1 but not anti-mCTLA4. Plots show mean±SEM.