How It Works
A piece of the patient’s living tumor is removed during surgery or biopsy and is implanted in mice. By implanting the tumor together with its microenvironment, Champions TumorGraft tumor models continue to very closely resemble the patient’s tumor, with 94 percent genetic correlation to the tumor in the patient. Approximately 65 percent of most tumor types implanted will grow successfully in mice.
While the Champions TumorGraft patient-derived xenograft (PDX) models are growing in the mice, the patient continues to receive regular cancer treatment therapy from their oncologist. This growth period generally takes two months or longer.
Our scientists work closely with treating physicians to determine which cancer drugs to test on the patient’s PDX model. Our labs will administer these cancer treatments to the mice and measure the living tumor’s response to each drug regimen. Physicians receive a robust report on the effectiveness of each tested cancer therapy on the PDX models. With this information in hand, physicians can personalize each patient’s cancer treatment therapy.
Every Champions TumorGraft® PDX model is preserved as a living sample for future patient use. These banked PDX models can be regrown and tested in the event of cancer progression or recurrence.
The entire process (implantation through testing) typically takes 4-6 months.