TumorGrafts Over Zenografts

Champions TumorGrafts are different than traditional xenografts.

Tumor fragments are transplanted directly from patient to mice:

  • Supporting stroma and cancer stem cells are maintained, thereby maintaining the important interactions between stroma and cancer cells.
  • Drug activity is assessed in original tumor microenvironment.
  • Tumor heterogeneity is maintained through drug-testing phase

Champions TumorGrafts™ are more accurate than traditional xenografts:

  • Histologically, tumors show a high degree of concordance between the original tumor and multiple passages in mice with regards to protein expression and stability.
    View example images.
  • Maintain high degree of mutational accuracy through TumorGraft expansion phases.
    View the patient journey.
  • Maintain a near perfect correlation in gene expression with the original tumor. (Correlation with standard xenografts is ~20%)
    View a comparison using microarray expression analysis.
  • Maintain a strong accuracy with clinical response to standard of care agents.
Champions Oncology - Specializing in | Personalized Cancer Therapy | Translational Oncology Solutions | Oncology drug development | Oncology drug discovery | Translational oncology | Translation oncology research | Predictive oncology | Patient-derived xenograft model | Tumorgrafts | Alternative/new cancer treatment | Anticancer therapies | Personalized cancer treatment | Personalized cancer therapy | Personalized oncology